If you’re shopping for an NAD+ booster in 2025, you’ve probably seen plenty of bold claims. In this head-to-head review I compare MITOLYN vs Tru Niagen, and Elysium Basis on ingredients, clinical evidence, safety, value, and real-world use — so you can pick the best option for your goals (energy, cellular health, or longevity-focused biohacking).
Quick verdict
Best clinical evidence: Tru Niagen / Elysium Basis (NR-backed studies). Best formula blend: MITOLYN (multi-ingredient energy stack). Best for straight NAD+ support: Tru Niagen (Niagen®) or Elysium Basis (NR + pterostilbene).
Comparison snapshot — top facts
Boost Your Mitochondria — Unlock Daily Energy
Boosts energy & metabolism
- ✅ Targets your body’s natural “cell energy trigger” for optimal performance
- Supports healthy weight management alongside balanced diet & activity
- No harsh stimulants — gentle, science-backed formulation
- Tru Niagen — contains patented nicotinamide riboside (NR/Niagen®); widely used in clinical studies and positioned as the NR category leader. Typical clinical doses studied range from 300 mg to 1000 mg/day depending on trial.
- Elysium Basis — mixes NR (NR-E) with pterostilbene; Basis studies reported ~40% average increase in cellular NAD+ at recommended dosing in older adults in their trial. Suggested use: 2 tablets daily (250 mg NR + 50 mg pterostilbene per serving).
- MITOLYN — marketed as a multi-ingredient “mitochondrial health / energy” supplement with antioxidants and cofactors (CoQ10 variants, botanical extracts). Public info and reviews are mixed; less clear clinical trial backing specifically for NAD+ vs the NR products. Verify ingredient label and supplier transparency before promoting.
In-depth sections
Ingredients & mechanism
- Tru Niagen: Niagen® (nicotinamide riboside), a direct NAD+ precursor studied in many human trials — raises blood NAD+ levels and has published clinical data.
- Elysium Basis: proprietary NR (NR-E) + pterostilbene (a polyphenol similar to resveratrol). Elysium cites placebo-controlled trials showing increased NAD+ in older adults.
- MITOLYN: ingredient lists reported to include antioxidants, CoQ10 (or ubiquinol), L-carnitine, plant polyphenols (e.g., maqui), and vitamin cofactors — a broader mitochondrial support blend rather than a pure NR/NMN NAD+ precursor. Documentation is less centralized and often relies on product pages and user reviews. Verify current label for the exact formula.
Takeaway: If your only goal is to reliably raise NAD+ levels using a precursor with strong published human studies, NR products (Tru Niagen, Elysium Basis) have clearer clinical backing. If you want a broader mitochondrial blend (antioxidants + cofactors), MITOLYN is positioned that way — but has less direct NAD+ trial evidence.
Clinical evidence & safety
- Tru Niagen / Niagen® has been used in dozens of human studies and clinical trials, and ChromaDex (maker) highlights this research. Many trials use 300–1000 mg/day NR in various contexts.
- Elysium Basis reports its placebo-controlled trials showing average NAD+ increases (e.g., ~40% in one trial of 60–80 year olds at the recommended dose). Basis publishing and trial summaries are available publicly.
- MITOLYN — independent clinical trials focused on MITOLYN specifically are not as prominent. Reviews and third-party articles discuss ingredients and anecdotal effects; proceed with cautious language when making health claims.
Safety note: NAD+ precursors are generally tolerated in clinical trials, but individual responses vary. Always recommend consulting a healthcare provider, especially for pregnant/lactating women, people on medications, or with chronic health conditions. General NAD+ research summaries are available in peer-reviewed literature.
Price & value
- Tru Niagen and Elysium Basis are premium-priced NR supplements backed by science; they often run subscription models and occasional discounts.
- MITOLYN is usually positioned as a value multi-ingredient formula; pricing and discounts vary by retailer. Verify current MSRP on the official product page before publishing.
Pros & cons
Tru Niagen
- Strong clinical backing for NR (many human studies).
- Simple ingredient list (easy to explain).
− Premium price for an NR-only product.
Elysium Basis
- Clinically reported increases in NAD+ with NR + pterostilbene.
- Two-ingredient approach supports cellular mechanisms.
− Some debate about long-term pterostilbene benefits and cost.
MITOLYN
- Multi-ingredient mitochondrial support (antioxidants + cofactors).
- May appeal to users seeking a broader “energy + mitochondria” formula.
− Less clear NAD+–specific clinical evidence; review product label and third-party testing.
Who should buy which?
- Choose Tru Niagen if you want a clinically validated NR product with a track record in human studies.
- Choose Elysium Basis if you like the NR + polyphenol combo and want a product tested in older adult trials
- Choose MITOLYN if you prefer a multi-ingredient mitochondrial blend and are targeting energy/antioxidant support rather than pure NR-driven NAD+ boosts. Verify labels and supplier transparency before promoting heavily.